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Title

Epigenetic dysregulation of TET2 in human glioblastoma

AuthorsGarcía, María G.; Carella, Antonella; Urdinguio, Rocío G.; Bayón, Gustavo F.; López, Virginia; Tejedor, Juan Ramón; Sierra, Marta I.; García-Toraño, Estela; Santamarina, Pablo; Pérez, Raúl F.; Mangas, Cristina; Astudillo, Aurora; Corte-Torres, M. Daniela; Sáenz-de-Santa-María, Inés; Chiara, María-Dolores; Fernández, Agustín F.; Fraga, Mario F.
KeywordsTET2
DNA methylation
Epigenetics
Glioblastoma
5-hydroxymehtylcytosine
Issue Date2018
PublisherImpact Journals
CitationOncotarget 9(40): 25922-25934 (2018)
AbstractTen-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of TET2 regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic dysregulation of TET2 plays a role in human glioblastoma.
Publisher version (URL)https://doi.org/10.18632/oncotarget.25406
URIhttp://hdl.handle.net/10261/173619
Identifiersdoi: 10.18632/oncotarget.25406
e-issn: 1949-2553
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