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Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass

AutorEsteban-Tejeda, Leticia; Zheng, Kai; Prado, Catuxa ; Cabal, Belén ; Torrecillas, Ramón ; Boccaccini, Aldo R.; Moya, J. S.
Palabras claveAntimicrobial
Soda-lime glass-ceramics
Scaffold
Fecha de publicación2016
EditorElsevier
CitaciónJournal of Non-Crystalline Solids 432A: 73-80 (2016)
ResumenThis paper reports the fabrication, microstructural characterization, mechanical properties and antimicrobial activity of scaffolds obtained from a soda-lime glass powder constituted by micro-spheres belonging to the SiO-NaO-AlO-CaO - BO system. Scaffolds with a porosity > 90% were fabricated using the foam replication method in the temperature range of 750-850 °C. The highest compressive strength value (0.2 MPa) was obtained for the scaffolds sintered at 850 °C. The observed mechanical properties were rationalized considering the scaffold singular microstructure of the struts constituted by a dense packing of microspheres ranging from 4 to 30 μm interlocked by nepheline needle-like crystals. The antimicrobial test was performed against three different microorganisms: Escherichia coli, Staphylococcus aureus and Candida krusei (yeast). A 45S5 Bioglass® scaffold was also tested for comparison. A window glass scaffold was used as control. In all cases a safe disinfection was obtained (reduction > 99.9% = log of reduction > 3). The antimicrobial activity was found to be similar to that of 45S5 Bioglass® based scaffolds. However, the soda-lime scaffold sintered at 850 °C exhibited a higher antimicrobial activity (log of reduction > 5 = reduction > 99.999%) against C. krusei, which is a microorganism resistant to multiples biocides, than the Bioglass® scaffold (log of reduction < 2 = reduction > 99.0%).
URIhttp://hdl.handle.net/10261/173169
Identificadoresdoi: 10.1016/j.jnoncrysol.2015.05.040
issn: 0022-3093
e-issn: 1873-4812
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