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Antimicrobial activity of submicron glass fibres incorporated as a filler to a dental sealer

AutorEsteban-Tejeda, Leticia; Cabal, Belén ; Torrecillas, Ramón ; Prado, Catuxa ; Fernández-García, Elisa ; López-Píriz, Roberto; Quintero, Félix; Pou, Juan; Penide, J.; Moya, J. S.
Fecha de publicación2016
EditorInstitute of Physics Publishing
CitaciónBiomedical Materials 11(4): 045014 (2016)
ResumenTwo types of antimicrobial glass fibers containing ZnO and CaO, with diameters ranging from tens of nanometers to 1 m, were successfully fabricated by a laser spinning technique. The antimicrobial performance was corroborated according to ISO 20743:2013, by using gram-negative (Escherichia coli) and gram-positive (Streptococcus oralis, Streptococcus mutans and Staphylococcus aureus) bacteria, and yeast (Candida krusei) (more than 3 logs of reduction). The metabolic activity and endosomal system of eukaryotic cells were not altered by using eluents of CaO glass submicrometric fibers and ZnO fibers at 1 : 10 dilution as cellular media (viability rates over 70%). A dental material was functionalized by embedding ZnO nanofibers above the percolation threshold (20% wt), creating a three-dimensional (3D) fiber network that added an antimicrobial profile. This new ZnO glass fiber composite is proved non-cytotoxic and preserved the antimicrobial effect after immersion in human saliva. This is the first time that a fiber-reinforced liner with strong antimicrobial-activity has been created to prevent secondary caries. The potential of developing new fiber-reinforced composites (FRCs) with antimicrobial properties opens up an extensive field of dental applications where most important diseases have an infectious origin.
URIhttp://hdl.handle.net/10261/173159
Identificadoresdoi: 10.1088/1748-6041/11/4/045014
e-issn: 1748-605X
issn: 1748-6041
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