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Impact of anorexia nervosa on immunological biomarkers

AutorNova, Esther ; Elegido, Ana; Díaz, L. E. ; Andrés, Patricia; Sepúlveda, Ana Rosa; Graell, Montserrat; Marcos, Ascensión
Palabras claveAdipokines
Lymphocyte subsets
Anorexia nervosa
Fecha de publicación2017
CitaciónInternational Symposium on Immunonutrition (2017)
ResumenAnorexia Nervosa (AN) affects all systems in the body and evidences have shown that multiple adaptive mechanisms are triggered under this metabolically and psychologically demanding situation which also involves the immune system. Leukopenia and relative lymphocytosis are among the most frequent abnormalities. In our follow-up study on AN patients, a group of 66 females, aged 12–17 years, referred for their first episode of either AN or Feeding or Eating Disorders Not Elsewhere Classified (FED-NEC) were studied upon admission (46 AN-restricting subtype, 11 ANbinge/purging subtype and 9 FED-NEC). Relative lymphocytosis was negatively correlated with Z-score BMI. In regression models, leptin explained even more variability in the lymphocyte percentage than BMI, suggesting that this is a leptin-mediated process. Furthermore, weight loss induced an increase of naïve CD4+ lymphocytes suggesting a priority to preserve adaptive immunity. Forty-one of the patients participated in a case-control study, matched by sex, age and socioeconomic status. The low leptin and increased adiponectin levels found in patients are in concordance with findings in the literature, and so are the high basal cortisol levels. However, the elevation of pro-inflammatory cytokines was not confirmed in these young patients with early diagnosis. One-year follow-up of blood biomarkers showed partial leptin recovery in parallel to BMI increase, while adiponectin remained high. There seems to be a delayed response of adiponectin to nutritional changes. Finally, inconsistencies are observed in the relationships between basal biomarker alterations and the severity of eating disorder psychopathology. Studying how these relationships change along with treatment should provide clues regarding the link between psychological factors and metabolic adjustments.
DescripciónResumen del trabajo presentado al International Symposium on Immunonutrition (10th Anniversary), celebrado en Madrid (España) del 17 al 19 de julio de 2017.
Aparece en las colecciones: (ICTAN) Comunicaciones congresos
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