English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/172000
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic acid (DHA) supplement on human sperm function

AuthorsGonzález-Ravina, Cristina; Aguirre-Lipperheide, Mercedes; Pinto Pérez, Francisco M. ; Martín-Lozano, David; Fernández-Sánchez, Manuel; Blasco, Víctor; Santamaría-López, Esther; Candenas, M. Luz
Oxidative stress
Issue DateJun-2018
CitationReproductive Biology, 18(3): 282-288 (2018)
AbstractThe aim of this study was to evaluate the possible beneficial effects of diet supplementation with a highly concentrated and purified docosahexaenoic acid (DHA) formula on human sperm function. We performed a prospective, randomized, double blind, placebo-controlled intervention study. One-hundred eighty human semen samples from sixty infertile patients recruited in a private assisted reproduction center were included. All samples were examined according to World Health Organization guidelines. We analyzed macroscopic and microscopic sperm parameters, oxidative stress, apoptosis, lipid peroxidation, mitochondrial membrane potential and DNA fragmentation before and after supplementation with different DHA daily doses (0.5, 1 and 2 g) or placebo for 1 and 3 months. No differences were found in traditional sperm parameters except for progressive sperm motility, with a significant increase after DHA ingestion after the first month with 1 or 2 g doses and after 3 months with 0.5 g of DHA. This effect was more evident in asthenozoospermic patients. No differences were found in any molecular semen parameter except oxidative stress, in which a slight benefit was observed after DHA treatment. In conclusion, this study support previous indications that highlight the importance of DHA supplementation as a means of improving sperm quality in asthenozoospermic men.
Publisher version (URL)https://doi.org/10.1016/j.repbio.2018.06.002
Appears in Collections:(IIQ) Artículos
Files in This Item:
File Description SizeFormat 
2018-Artículo DHA-NO MAQUETADO-Reproductive Biology.pdf129,2 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.