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dc.contributor.authorMoreno, María Alejandraes_ES
dc.contributor.authorGómez-Mascaraque, Laura G.es_ES
dc.contributor.authorArias, Myriames_ES
dc.contributor.authorZampini, Iris Catianaes_ES
dc.contributor.authorSayago, Jorge Estebanes_ES
dc.contributor.authorPino Ramos, Leidy Liudises_ES
dc.contributor.authorSchmeda-Hirschmann, Guillermoes_ES
dc.contributor.authorLópez-Rubio, Amparoes_ES
dc.contributor.authorIsla, María Inéses_ES
dc.identifier.citationCarbohydrate Polymers 201: 425-437 (2018)es_ES
dc.description.abstractThe design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the extracts, which explained why the microcapsules kept the integrity in slightly acidic media. Increased solubility of the extracts when incorporated in the microcapsules was seen in simulated vaginal fluid, potentially increasing the bioavailability of bioactive compounds in the vaginal environment.es_ES
dc.description.sponsorshipThis research was supported by grants from Secretaría de Ciencia, Arte e Innovación Tecnológica de la Universidad Nacional de Tucumán, Argentina (SCAIT-UNT), Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina (CONICET), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), Universidad de Talca, Chile (PIEI-QUIM-BIO) and EMHE-CSIC (Grant MHE-200038). L. G. Gómez-Mascaraque, is recipient of a predoctoral contract (BES-2013-065883) from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO). The authors thank the Central Support Service for Experimental Research (SCSIE) of the University of Valencia for the electronic microscopy service.es_ES
dc.subjectArgentinean dry plant extractses_ES
dc.subjectVaginal tabletses_ES
dc.titleElectrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulationses_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderUniversidad Nacional de Tucumánes_ES
dc.contributor.funderConsejo Nacional de Investigaciones Científicas y Técnicas (Argentina)es_ES
dc.contributor.funderAgencia Nacional de Promoción Científica y Tecnológica (Argentina)es_ES
dc.contributor.funderUniversidad de Talcaes_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)es_ES
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