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http://hdl.handle.net/10261/171699
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dc.contributor.author | Corrales-Guerrero, Laura | - |
dc.contributor.author | Camargo, Sergio | - |
dc.contributor.author | Valladares, Ana | - |
dc.contributor.author | Picossi, Silvia | - |
dc.contributor.author | Luque, Ignacio | - |
dc.contributor.author | Ochoa de Alda, Jesús A.G. | - |
dc.contributor.author | Herrero, Antonia | - |
dc.date.accessioned | 2018-10-29T12:27:10Z | - |
dc.date.available | 2018-10-29T12:27:10Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.3389/fmicb.2018.02260 | - |
dc.identifier | issn: 1664-302X | - |
dc.identifier.citation | Frontiers in Microbiology 9: 2260 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/171699 | - |
dc.description.abstract | Filamentous cyanobacteria grow by intercalary cell division, which should involve distinct steps compared to those producing separate daughter cells. The N-terminal region of FtsZ is highly conserved in the clade of filamentous cyanobacteria capable of cell differentiation. A derivative of the model strain Anabaena sp. PCC 7120 expressing only an FtsZ lacking the amino acids 2¿51 of the N-terminal peptide (1N-FtsZ) could not be segregated. Strain CSL110 expresses both 1N-FtsZ, from the endogenous ftsZ gene promoter, and the native FtsZ from a synthetic regulated promoter. Under conditions of 1N-FtsZ predominance, cells of strain CSL110 progressively enlarge, reflecting reduced cell division, and show instances of asymmetric cell division and aberrant Z-structures notably differing from the Z-ring formed by FtsZ in the wild type. In bacterial 2-hybrid assays FtsZ interacted with 1N-FtsZ. However, 1N-FtsZ-GFP appeared impaired for incorporation into Z-rings when expressed together with FtsZ. FtsZ, but not 1N-FtsZ, interacted with the essential protein SepF. Both FtsZ and 1N-FtsZ polymerize in vitro exhibiting comparable GTPase activities. However, filaments of FtsZ show a distinct curling forming toroids, whereas 1N-FtsZ form thick bundles of straight filaments. Thus, the N-terminal FtsZ sequence appears to contribute to a distinct FtsZ polymerization mode that is essential for cell division and division plane location in Anabaena. | - |
dc.publisher | Frontiers Media | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Cell division | - |
dc.subject | Cyanobacterial FtsZ phylogeny | - |
dc.subject | ZipN phylogeny | - |
dc.subject | Bacterial multicellularity | - |
dc.subject | Anabaena | - |
dc.title | FtsZ of Filamentous, Heterocyst-Forming Cyanobacteria Has a Conserved N-Terminal Peptide Required for Normal FtsZ Polymerization and Cell Division | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3389/fmicb.2018.02260 | - |
dc.date.updated | 2018-10-29T12:27:10Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.relation.csic | Sí | - |
dc.identifier.pmid | 30333801 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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