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http://hdl.handle.net/10261/171577
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dc.contributor.author | González Peña, Diana | - |
dc.contributor.author | Dudzik, Danuta | - |
dc.contributor.author | Colina Coca, Clara | - |
dc.contributor.author | Ancos, Begoña de | - |
dc.contributor.author | García, Antonia | - |
dc.contributor.author | Barbas, Coral | - |
dc.contributor.author | Sánchez-Moreno, Concepción | - |
dc.date.accessioned | 2018-10-25T10:32:23Z | - |
dc.date.available | 2018-10-25T10:32:23Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1007/s00394-015-0914-1 | - |
dc.identifier | e-issn: 1436-6215 | - |
dc.identifier | issn: 1436-6207 | - |
dc.identifier.citation | European Journal of Nutrition 55(3): 997-1010 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/171577 | - |
dc.description.abstract | [Purpose]: The aim was to investigate the impact of hypercholesterolemic diet on the metabolome of male Wistar rats by a multiplatform metabolomic fingerprinting. [Methods]: Male Wistar rats were fed with two different diets [control (C) and high-cholesterol diet (HC)—containing 2 % cholesterol and 0.5 % cholic acid]. After 7 weeks of experimental feeding, the rats were euthanized for blood collection and plasma recovery. The metabolite fingerprint was then achieved by applying a multiplatform comprising LC–MS, GC–MS and CE–MS. [Results]: Multivariate statistical analysis showed a clear separation between the C and HC groups. Individual differences in metabolites were evaluated using univariate statistical analysis, and multiple metabolites were identified and confirmed in the plasma. A global profiling integrates for the first time pathways affected by high-cholesterol diet intake and allowed us to elucidate some of the associated alterations underlying the hypercholesterolemia event in Wistar rats. [Conclusions]: HC feeding stimulated the alteration of multiple pathways in Wistar rats, warning of the risk of developing important diseases, which can be modulated by the diet. Further studies are required to investigate the possibilities to revert or ameliorate the negative effects triggered by HC intake. | - |
dc.description.sponsorship | The study was supported by the Spanish Ministry of Science and Innovation [AGL2010-15910 (subprogram ALI)] and the Spanish Ministry of Economy and Competitiveness (CTQ2014-55279-R). The following projects are also acknowledged: Program Consolider-Ingenio 2010, FUN-C-FOOD, CSD2007-00063 (Spanish Ministry of Science and Innovation), and ALIBIRD, S2009/AGR-1469 (Comunidad de Madrid). | - |
dc.publisher | Springer Nature | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-55279-R | - |
dc.relation | S2009/AGR-1469/ALIBIRD | - |
dc.rights | closedAccess | - |
dc.subject | Atherosclerosis | - |
dc.subject | Untargeted analysis | - |
dc.subject | Metabolomics | - |
dc.subject | High-cholesterol diet | - |
dc.subject | Global profiling | - |
dc.title | Multiplatform metabolomic fingerprinting as a tool for understanding hypercholesterolemia in Wistar rats | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1007/s00394-015-0914-1 | - |
dc.date.updated | 2018-10-25T10:32:23Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.pmid | 25967353 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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