English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/171299
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Título

Retention of fatty acyl desaturase 1 (fads1) in elopomorpha and cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates

AutorLopes-Marques, Mónica; Kabeya, Naoki; Qian, Yu; Ruivo, Raquel; Santos, Miguel M.; Venkatesh, Byrappa; Tocher, Douglas R.; Castro, L. F. C.; Monroig, Óscar
Palabras claveBiosynthesis
Fatty acyl desaturase
Gene duplication
Gene loss
Long-chain polyunsaturated fatty acids
Fecha de publicación19-oct-2018
EditorBioMed Central
CitaciónBMC Evolutionary Biology 18(1): 157
Resumen[Background] Provision of long-chain polyunsaturated fatty acids (LC-PUFA) in vertebrates occurs through the diet or via endogenous production from C18 precursors through consecutive elongations and desaturations. It has been postulated that the abundance of LC-PUFA in the marine environment has remarkably modulated the gene complement and function of Fads in marine teleosts. In vertebrates two fatty acyl desaturases, namely Fads1 and Fads2, encode ∆5 and ∆6 desaturases, respectively. To fully clarify the evolutionary history of LC-PUFA biosynthesis in vertebrates, we investigated the gene repertoire and function of Fads from species placed at key evolutionary nodes.
[Results] We demonstrate that functional Fads1Δ5 and Fads2∆6 arose from a tandem gene duplication in the ancestor of vertebrates, since they are present in the Arctic lamprey. Additionally, we show that a similar condition was retained in ray-finned fish such as the Senegal bichir and spotted gar, with the identification of fads1 genes in these lineages. Functional characterisation of the isolated desaturases reveals the first case of a Fads1 enzyme with ∆5 desaturase activity in the Teleostei lineage, the Elopomorpha. In contrast, in Osteoglossomorpha genomes, while no fads1 was identified, two separate fads2 duplicates with ∆6 and ∆5 desaturase activities respectively were uncovered.
[Conclusions] We conclude that, while the essential genetic components involved LC-PUFA biosynthesis evolved in the vertebrate ancestor, the full completion of the LC-PUFA biosynthesis pathway arose uniquely in gnathostomes.
Versión del editorhttps://doi.org/10.1186/s12862-018-1271-5
URIhttp://hdl.handle.net/10261/171299
DOI10.1186/s12862-018-1271-5
ISSN1471-2148
Aparece en las colecciones: (IATS) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
retention_vertebrates.pdf1,42 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.