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Exploiting the commons: Cyclic diguanylate regulation of bacterial exopolysaccharide production

AuthorsPérez-Mendoza, Daniel; Sanjuán, Juan
Issue Date2016
CitationCurrent Opinion in Microbiology 30: 36- 43 (2016)
AbstractNowadays, there is increasing interest for bacterial polysaccharides in a wide variety of industrial sectors. This is due to their chemical and reological properties, and also the possibility to be obtained by fermentation processes. Biosynthesis of a growing number of exopolysaccharides (EPS) has been reported to be regulated by the ubiquitous second messenger c-di-GMP in a limited number of bacterial species. Since most bacteria are yet unexplored, it is likely that an unsuspected number and variety of EPS structures activated by c-di-GMP await to be uncovered. In the search of new EPS, manipulation of bacterial c-di-GMP metabolism can be combined with high throughput approaches for screening of large collections of bacteria. In addition, c-di-GMP activation of EPS production and promotion of cell aggregation may have direct applications in environmental industries related with biofuel production or wastewater treatments.
Identifiersdoi: 10.1016/j.mib.2015.12.004
issn: 1879-0364
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