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Título: | A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats |
Autor: | Molinar-Toribio, Eunice; Fuguet, Elisabet CSIC; Ramos-Romero, Sara CSIC ORCID; Taltavull, Núria; Méndez, Lucía CSIC ORCID; Nogués, M. R.; Medina, Isabel CSIC ORCID ; Pérez-Jiménez, Jara CSIC ORCID | Palabras clave: | Metabolites Bioavailability High-fat high-sucrose diet Proanthocyanidins Polyphenols |
Fecha de publicación: | 2018 | Editor: | Springer Nature | Citación: | European Journal of Nutrition 57(1): 339-349 (2018) | Resumen: | [Purpose]: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). [Methods]: Adult female Wistar–Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC–MS/MS analysis. [Results]: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. [Conclusions]: These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes. | Versión del editor: | https://doi.org/10.1007/s00394-016-1323-9 | URI: | http://hdl.handle.net/10261/170831 | DOI: | 10.1007/s00394-016-1323-9 | Identificadores: | doi: 10.1007/s00394-016-1323-9 e-issn: 1436-6215 issn: 1436-6207 |
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