English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/170615
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Citrate gold nanoparticle exposure in the marine bivalve Ruditapes philippinarum: uptake, elimination and oxidative stress response

AuthorsVolland, Moritz; Hampel, Miriam ; Martos-Sitcha, Juan Antonio ; Trombini, Chiara ; Martínez-Rodríguez, Gonzalo ; Blasco, Julián
KeywordsAu-nanoparticles
Accumulation
Elimination
q-PCR
Nanotoxicity
Redox homeostasis
Issue DateNov-2015
PublisherSpringer Nature
CitationEnvironmental science and pollution research international 22(22): 17414-17424 (2015)
AbstractGold nanoparticles (AuNPs) are considered an important nano-sized component of the twenty-first century. Due to their unique physical and chemical properties, they are being used and developed for a wide range of promising applications in medicine, biology and chemistry. Notwithstanding their useful aspects, in recent years concern has been raised over their ability to enter cells, organelles and nuclei and provoke oxidative stress. In a laboratory-based experiment, the non-target marine bivalve Ruditapes philippinarum was used as a model organism. Uptake, elimination and molecular effects under short-term and sub-chronic exposure conditions to an environmental relevant concentration (0.75 μg L−1) of weakly agglomerating citrate AuNPs (∼20 nm) were studied. Our results demonstrate that at the tested concentration, the particles are readily taken up into the digestive gland > gills and can produce significant changes (p < 0.05) in oxidative stress and inflammatory response markers, as measured by phase II antioxidant enzymes and q-PCR gene expression analysis. However, the overall magnitude of responses was low, and oxidative damage was not provoked. Further, a significant elimination of Au from the digestive tract within a 7-day purification period was observed, with excretion being an important pathway. In conclusion, short-term and sub-chronic exposure to an environmental relevant concentration of citrate-stabilized AuNPs cannot be considered toxic to our model organism, while some further consideration should be given to chronic exposure effects.
Publisher version (URL)http://dx.doi.org/10.1007/s11356-015-4718-x
URIhttp://hdl.handle.net/10261/170615
DOI10.1007/s11356-015-4718-x
ISSN0944-1344
E-ISSN1614-7499
Appears in Collections:(ICMAN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.