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Título: | Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis |
Autor: | Zhang, Wuyuan; Burek, Bastian O.; Fernández-Fueyo, Elena CSIC ORCID; Alcalde Galeote, Miguel CSIC ORCID ; Bloh, Jonathan Z.; Hollmann, Frank | Palabras clave: | Biocatalysis Oxyfunctionalization Peroxygenases Photocatalysis TiO 2 |
Fecha de publicación: | 27-nov-2017 | Editor: | John Wiley & Sons | Citación: | Angewandte Chemie - International Edition 56(48): 15451-15455 (2017) | Resumen: | Selective oxyfunctionalizations of inert C−H bonds can be achieved under mild conditions by using peroxygenases. This approach, however, suffers from the poor robustness of these enzymes in the presence of hydrogen peroxide as the stoichiometric oxidant. Herein, we demonstrate that inorganic photocatalysts such as gold–titanium dioxide efficiently provide H2O2 through the methanol‐driven reductive activation of ambient oxygen in amounts that ensure that the enzyme remains highly active and stable. Using this approach, the stereoselective hydroxylation of ethylbenzene to (R)‐1‐phenylethanol was achieved with high enantioselectivity (>98 % ee) and excellent turnover numbers for the biocatalyst (>71 000). | Versión del editor: | https://doi.org/10.1002/anie.201708668 | URI: | http://hdl.handle.net/10261/170424 | DOI: | 10.1002/anie.201708668 | ISSN: | 1433-7851 | E-ISSN: | 1521-3773 |
Aparece en las colecciones: | (ICP) Artículos (CIB) Artículos |
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AngewChemIntEd2017.pdf | 1,81 MB | Adobe PDF | Visualizar/Abrir |
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