English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/169752
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Engineering and monitoring cellular barrier models

AuthorsYeste Lozano, José; Illa, Xavi; Alvarez, Mar; Villa, Rosa
KeywordsBiological barriers
Cell barrier function
Microphysiological systems
Transepithelial electrical properties
Issue Date12-Sep-2018
PublisherBioMed Central
CitationJournal of Biological Engineering 12(1): 18 (2018)
AbstractEpithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is associated with numerous human diseases. Recent advances in biomaterials and microfabrication technologies have evolved in vitro approaches for modelling biological barriers. Current microphysiological systems have become more efficient and reliable in mimicking the cell microenvironment. Additionally, methods for the quantification of barrier permeability have long provided significant insight into their underlying mechanisms. In this review, we outline the current techniques to quantify the barrier function of engineered tissues, and we also give an overview of recent microphysiological systems of biological barriers that emulate the microenvironment and microarchitecture of native tissues.
Publisher version (URL)https://doi.org/10.1186/s13036-018-0108-5
URIhttp://hdl.handle.net/10261/169752
DOI10.1186/s13036-018-0108-5
ISSN1754-1611
Appears in Collections:(IMB-CNM) Artículos
Files in This Item:
File Description SizeFormat 
engineering_models_2018.pdf4,46 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.