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dc.contributor.authorUhlig, Manuel R.es_ES
dc.contributor.authorAmo, Carlos A.es_ES
dc.contributor.authorGarcía García, Ricardoes_ES
dc.date.accessioned2018-09-11T07:57:07Z-
dc.date.available2018-09-11T07:57:07Z-
dc.date.issued2018-09-05-
dc.identifier.citationNanoscale 10: 17112-17116 (2018)es_ES
dc.identifier.issn2040-3364-
dc.identifier.urihttp://hdl.handle.net/10261/169531-
dc.description.abstractAtomic force microscope based single-molecule force spectroscopy provides a description of a variety of intermolecular interactions such as those occurring between receptor molecules and their ligands. Advances in force spectroscopy have enabled performing measurements at high-speeds and sub-microsecond resolutions. We report experiments performed on a biotin–avidin system that reveal that the measured force decreases with the loading rate at high rates. This result is at odds with the established Bell–Evans theory that predicts a monotonic increase of the rupture force with the loading rate. We demonstrate that inertial and hydrodynamic forces generated during the breaking of the bond dominate the measured force at high loading rates. We develop a correction factor to incorporate those effects into the Bell–Evans theory. The correction is necessary to obtain accurate values of the intermolecular forces at high speeds.es_ES
dc.description.sponsorshipWe thank Peter Hinterdorfer, Daniel J. Muller and Andra C. Dumitru for motivating discussions and revising the Ms Financial support from the European Research Council ERC-AdG-340177 (3DNanoMech) and the Ministerio de Economía y Competitividad for grant MAT2016-76507-R is acknowledged. The fellowship FPU15/04622 from the Ministerio de Educación is also acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistry (UK)es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340177es_ES
dc.relationMINECO/ICTI2013-2016/MAT2016-76507-Res_ES
dc.relation.isversionofPostprintes_ES
dc.rightsembargoedAccesses_ES
dc.titleDynamics of breaking intermolecular bonds in high-speed force spectroscopyes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1039/C8NR05715J-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1039/C8NR05715Jes_ES
dc.identifier.e-issn2040-3372-
dc.embargo.terms2019-09-05es_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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