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dc.contributor.authorJaraíz-Rodríguez, Myriam-
dc.contributor.authorTabernero, María D.-
dc.contributor.authorGonzález-Tablas, María-
dc.contributor.authorOtero, Álvaro-
dc.contributor.authorOrfao, Alberto-
dc.contributor.authorMedina, Jose M.-
dc.contributor.authorTabernero, Arantxa-
dc.date.accessioned2018-08-30T07:32:32Z-
dc.date.available2018-08-30T07:32:32Z-
dc.date.issued2017-
dc.identifierdoi: 10.1016/j.stemcr.2017.06.007-
dc.identifiere-issn: 2213-6711-
dc.identifier.citationStem Cell Reports 9(2): 451-463 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/169240-
dc.description.abstractConnexin43 (CX43), a protein that forms gap junction channels and hemichannels in astrocytes, is downregulated in high-grade gliomas. Its relevance for glioma therapy has been thoroughly explored; however, its positive effects on proliferation are counterbalanced by its effects on migration and invasion. Here, we show that a cell-penetrating peptide based on CX43 (TAT-Cx43) inhibited c-Src and focal adhesion kinase (FAK) and upregulated phosphatase and tensin homolog in glioma stem cells (GSCs) derived from patients. Consequently, TAT-Cx43 reduced GSC motility, as analyzed by time-lapse microscopy, and strongly reduced their invasive ability. Interestingly, we investigated the effects of TAT-Cx43 on freshly removed surgical specimens as undissociated glioblastoma blocks, which revealed a dramatic reduction in the growth, migration, and survival of these cells. In conclusion, a region of CX43 (amino acids 266–283) exerts an important anti-tumor effect in patient-derived glioblastoma models that includes impairment of GSC migration and invasion.-
dc.description.sponsorshipThis work was supported by the Ministerio de Economía y Competitividad, Spain (FEDER BFU2015-70040-R), Junta de Castilla y León, Spain (FEDER SA026U16), and Fundación Ramón Areces. M.J.-R. was a fellowship recipient from the Junta de Castilla y León and the European Social Fund.-
dc.publisherElsevier-
dc.relationMINECO/ICTI2013-2016/BFU2015-70040-R-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleA short region of connexin43 reduces human glioma stem cell migration, invasion, and survival through Src, PTEN, and FAK-
dc.typeArtículo-
dc.relation.publisherversionhttps://doi.org/10.1016/j.stemcr.2017.06.007-
dc.date.updated2018-08-30T07:32:33Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderJunta de Castilla y León-
dc.contributor.funderFundación Ramón Areces-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
dc.identifier.pmid28712848-
Appears in Collections:(IBMCC) Artículos
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