English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/169197
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Functional insights into the cellular response triggered by a bile-acid platinum compound conjugated to biocompatible ferric nanoparticles using quantitative proteomic approaches

AutorDíez, Paula; González-Muñoz, María; González González, María; Dégano, Rosa M.; Jara-Acevedo, Ricardo; Sánchez-Paradinas, Sara; Piñol, Rafael; Murillo, José Luis; Lou, Gustavo; Palacio, Fernando; Almendral Parra, María Jesús; Millán, Ángel; Rodríguez-Fernández, Emilio; Criado, Julio J.; Ibarrola, Nieves ; Fuentes, Manuel
Fecha de publicación2017
EditorRoyal Society of Chemistry (Great Britain)
CitaciónNanoscale 9(28): 9960-9972 (2017)
ResumenAt present, bioferrofluids are employed as powerful multifunctional tools for biomedical applications such as drug delivery, among others. The present study explores the cellular response evoked when bile-acid platinum derivatives are conjugated with bioferrofluids by testing the biological activity in osteosarcoma (MG-63) and T-cell leukemia (Jurkat) cells. The aim of this work is to evaluate the biocompatibility of a bile-acid platinum derivative conjugated with multi-functional polymer coated bioferrofluids by observing the effects on the protein expression profiles and in intracellular pathways of nanoparticle-stimulated cells. To this end, a mass spectrometry-based approach termed SILAC has been applied to determine in a high-throughput manner the key proteins involved in the cellular response process (including specific quantitatively identified proteins related to the vesicular transport, cellular structure, cell cycle, biosynthetic process, apoptosis and regulation of the cell cycle). Finally, biocompatibility was evaluated and validated by conventional strategies also (such as flow cytometry, MTT, etc.).
URIhttp://hdl.handle.net/10261/169197
Identificadoresdoi: 10.1039/C7NR02196H
e-issn: 2040-3372
issn: 2040-3364
Aparece en las colecciones: (ICMA) Artículos
(IBMCC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.