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Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations

AuthorsPérez, Pablo ; Huertas, Gloria ; Olmo, Alberto; Maldonado, Andrés ; Serrano, Juan A.; Martín, María E.; Daza, Paula; Yúfera, A.
KeywordsSmart sensing
Cell culture
Real-time monitoring
Issue Date3-Aug-2018
PublisherMultidisciplinary Digital Publishing Institute
CitationSensors 18(8): 2550 (2018)
AbstractA smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable “biological” oscillator. The system enables the remote acquisition and management of the “biological” oscillation signals through a secure web interface. The indirectly observed biological properties are cell growth and cell number, which are straightforwardly related to the measured bio-oscillation signal parameters, i.e., frequency and amplitude. The sensor extracts the information without complex circuitry for acquisition and measurement, taking advantage of the microcontroller features. A discrete prototype for sensing and remote monitoring is presented along with the experimental results obtained from the performed measurements, achieving the expected performance and outcomes.
Publisher version (URL)https://doi.org/10.3390/s18082550
Appears in Collections:(IMSE-CNM) Artículos
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