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Title

Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms

AuthorsGalay-Burgos, Malyka; Gealy, Claire; Navarro-Martín, Laia ; Piferrer, Francesc ; Zanuy, Silvia ; Sweeney, Glen E.
KeywordsAromatase
Promoter
Sea bass
Gonadal
SF-1
Sex differentiation
Gene expression
SNPs
Issue Date30-Apr-2006
PublisherElsevier
CitationComparative Biochemistry and Physiology Part A 145(1): 47-53 (2006)
AbstractAromatase contributes to sex differentiation by catalysing the conversion of androgens into estrogens. We have cloned the promoter of the gonadal aromatase gene from the sea bass, Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved binding site for SF-1 as well as two cAMP response elements (CREs) and putative binding sites for transcription factors belonging to the Sox and forkhead families. Analysis of promoter sequences from individual fish suggests the presence of three promoter alleles that arise due to three single nucleotide polymorphisms (SNPs) in linkage disequilibrium.
Description7 pages, 3 figures.-- PMID: 16782377 [PubMed].-- Printed version published Sep 2006.
Publisher version (URL)http://dx.doi.org/10.1016/j.cbpa.2006.04.028
URIhttp://hdl.handle.net/10261/16885
DOI10.1016/j.cbpa.2006.04.028
ISSN1095-6433
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(IATS) Artículos
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