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Título: | Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies |
Autor: | Ocaña, Alberto; Pandiella, Atanasio CSIC ORCID CVN | Palabras clave: | Breast cancer Novel therapies Kinases Triple negative breast cancer |
Fecha de publicación: | 2017 | Editor: | Impact Journals | Citación: | Oncotarget 8(13): 22218-22234 (2017) | Resumen: | Triple negative breast cancer (TNBC) is still an incurable disease despite the great scientific effort performed during the last years. The huge heterogeneity of this disease has motivated the evaluation of a great number of therapies against different molecular alterations. In this article, we review the biological bases of this entity and how the known molecular evidence supports the current preclinical and clinical development of new therapies. Special attention will be given to ongoing clinical studies and potential options for future drug combinations. | Versión del editor: | https://doi.org/10.18632/oncotarget.14731 | URI: | http://hdl.handle.net/10261/168806 | DOI: | 10.18632/oncotarget.14731 | Identificadores: | doi: 10.18632/oncotarget.14731 e-issn: 1949-2553 |
Aparece en las colecciones: | (IBMCC) Artículos |
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targetstudie.pdf | 1,56 MB | Adobe PDF | Visualizar/Abrir |
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