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Título: | Could vitamin D analogues be used to target leukemia stem cells? |
Autor: | García-Ramírez, Idoia CSIC; Martín-Lorenzo, Alberto CSIC ORCID; González-Herrero, Inés CSIC ORCID; Rodríguez-Hernández, Guillermo CSIC ORCID ; Vicente-Dueñas, Carolina CSIC ORCID; Sánchez García, Isidro CSIC ORCID | Palabras clave: | Stem cells Vitamin D Cancer Cancer stem cells Mouse models Leukemia therapy |
Fecha de publicación: | 2016 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 17(6): 889 (2016) | Resumen: | Leukemic stem cells (LSCs) are defined as cells that possess the ability to self-renew and give rise to the differentiated cancer cells that comprise the tumor. These LSCs seem to show chemo-resistance and radio-resistance leading to the failure of conventional cancer therapies. Current therapies are directed at the fast growing tumor mass leaving the LSC fraction untouched. Eliminating LSCs, the root of cancer origin and recurrence, is considered to be a hopeful approach to improve survival or even to cure cancer patients. In order to achieve this, the characterization of LSCs is a prerequisite in order to develop LSC-based therapies to eliminate them. Here we review if vitamin D analogues may allow an avenue to target the LSCs. | Versión del editor: | https://doi.org/10.3390/ijms17060889 | URI: | http://hdl.handle.net/10261/168468 | DOI: | 10.3390/ijms17060889 | Identificadores: | doi: 10.3390/ijms17060889 e-issn: 1422-0067 issn: 1661-6596 |
Aparece en las colecciones: | (IBMCC) Artículos |
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Dvitamincell.pdf | 1,3 MB | Adobe PDF | Visualizar/Abrir |
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