Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/168404
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Altered neutrophil immunophenotypes in childhood B-cell precursor acute lymphoblastic leukemia |
Autor: | Oliveira, Elen; Bacelar, Thiago S.; Ciudad, Juana; Ribeiro, Maria Cecilia M.; Garcia, Daniel R. N.; Sedek, Lukasz; Maia, Simone F.; Aranha, Daniel B.; Machado, Indyara C.; Ikeda, Lisandra A. C.; Szczepanski, Tomasz; Silva, Maria Luiza M.; Land, Marcelo G. P.; Orfao, Alberto CSIC ORCID ; Costa, Elaine S. | Palabras clave: | Childhood Residual hematopoiesis B-cell precursor acute lymphoblastic leukemia Multiparameter flow cytometry Altered neutrophil immunophenotype |
Fecha de publicación: | 2016 | Editor: | Impact Journals | Citación: | Oncotarget 7(17): 24664-24676 (2016) | Resumen: | An increasing number of evidences suggest a genetic predisposition in acute lymphoblastic leukemia (ALL) that might favor the occurrence of the driver genetic alterations. Such genetic background might also translate into phenotypic alterations of residual hematopoietic cells. Whether such phenotypic alterations are present in bone marrow (BM) cells from childhood B-cell precursor (BCP)-ALL remains to be investigated. Here we analyzed the immunophenotypic profile of BM and peripheral blood (PB) maturing/matured neutrophils from 118 children with BCP-ALL and their relationship with the features of the disease. Our results showed altered neutrophil phenotypes in most (77%) BCP-ALL cases. The most frequently altered marker was CD10 (53%), followed by CD33 (34%), CD13 (15%), CD15/CD65 (10%) and CD123 (7%). Of note, patients with altered neutrophil phenotypes had younger age (p = 0.03) and lower percentages of BM maturing neutrophils (p = 0.004) together with greater BM lymphocyte (p = 0.04), and mature B-cell (p = 0.03) counts. No significant association was found between an altered neutrophil phenotype and other disease features. These findings point out the potential existence of an altered residual hematopoiesis in most childhood BCP-ALL cases. | Versión del editor: | https://doi.org/10.18632/oncotarget.8369 | URI: | http://hdl.handle.net/10261/168404 | DOI: | 10.18632/oncotarget.8369 | Identificadores: | doi: 10.18632/oncotarget.8369 e-issn: 1949-2553 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
altereleuke.pdf | 2,37 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 28-mar-2024
SCOPUSTM
Citations
7
checked on 20-mar-2024
WEB OF SCIENCETM
Citations
5
checked on 29-feb-2024
Page view(s)
453
checked on 27-mar-2024
Download(s)
200
checked on 27-mar-2024