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Title

Diacetyl and acetoin production from whey permeate using engineered Lactobacillus casei

AuthorsNadal, Inmaculada CSIC; Rico, Juan CSIC ORCID; Pérez Martínez, Gaspar CSIC ORCID ; Yebra, María Jesús CSIC ORCID; Monedero, Vicente CSIC ORCID
KeywordsLactobacillus
Metabolic engineering
Diacetyl
Acetoin
Whey permeate
Issue Date18-Jul-2009
PublisherSpringer
CitationJournal of Industrial Microbiology and Biotechnology 36(9): 1233-1237 (2009)
AbstractThe capability of Lactobacillus casei to produce the flavor-related compounds diacetyl and acetoin from whey permeate has been examined by a metabolic engineering approach. An L. casei strain in which the ilvBN genes from Lactococcus lactis, encoding acetohydroxyacid synthase, were expressed from the lactose operon was mutated in the lactate dehydrogenase gene (ldh) and in the pdhC gene, which codes for the E2 subunit of the pyruvate dehydrogenase complex. The introduction of these mutations resulted in an increased capacity to synthesize diacetyl/acetoin from lactose in whey permeate (1,400 mg/l at pH 5.5). The results showed that L. casei can be manipulated to synthesize added-value metabolites from dairy industry by-products.
Description5 pages, 3 figures.-- PMID: 19609583 [PubMed].-- Printed version published Sep 2009.
Publisher version (URL)http://dx.doi.org/10.1007/s10295-009-0617-9
URIhttp://hdl.handle.net/10261/16836
DOI10.1007/s10295-009-0617-9
ISSN1367-5435
E-ISSN1476-5535
Appears in Collections:(IATA) Artículos




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