Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/165675
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors |
Autor: | Martín-Montalvo, Alejandro CSIC ORCID; Lorenzo, Petra Isabel CSIC ORCID; López-Noriega, Livia CSIC ORCID; Gauthier, Benoit R. CSIC ORCID | Palabras clave: | PAX6 PAX2 Pancreatic neuroendocrine tumors PAX8 PAX genes Diabetes mellitus PAX4 |
Fecha de publicación: | 2017 | Editor: | Taylor & Francis | Citación: | Expert Opinion on Therapeutic Targets 21(1): 77-89 (2017) | Resumen: | [Introduction]: Four members of the PAX family, PAX2, PAX4, PAX6 and PAX8 are known to be expressed in the pancreas. Accumulated evidences indicate that several pancreatic expressed PAX genes play a significant role in pancreatic development/functionality and alterations in these genes are involved in the pathogenesis of pancreatic diseases. [Areas covered]: In this review, we summarize the ongoing research related to pancreatic PAX genes in diabetes mellitus and pancreatic neuroendocrine tumors. We dissect the current knowledge at different levels; from mechanistic studies in cell lines performed to understand the molecular processes controlled by pancreatic PAX genes, to in vivo studies using rodent models that over-express or lack specific PAX genes. Finally, we describe human studies associating variants on pancreatic-expressed PAX genes with pancreatic diseases. [Expert opinion]: Based on the current literature, we propose that future interventions to treat pancreatic neuroendocrine tumors and diabetes mellitus could be developed via the modulation of PAX4 and/or PAX6 regulated pathways. | URI: | http://hdl.handle.net/10261/165675 | DOI: | 10.1080/14728222.2017.1257000 | Identificadores: | doi: 10.1080/14728222.2017.1257000 e-issn: 1744-7631 issn: 1472-8222 |
Aparece en las colecciones: | (CABIMER) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 12-abr-2024
SCOPUSTM
Citations
16
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
13
checked on 29-feb-2024
Page view(s)
256
checked on 19-abr-2024
Download(s)
129
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.