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dc.contributor.authorRodríguez-Mateo, Cristina-
dc.contributor.authorTorres, Belén-
dc.contributor.authorGutiérrez, Gabriel-
dc.contributor.authorPintor-Toro, José Antonio-
dc.identifierdoi: 10.1038/cdd.2017.9-
dc.identifiere-issn: 1476-5403-
dc.identifierissn: 1350-9047-
dc.identifier.citationCell Death and Differentiation 24(5): 785-797 (2017)-
dc.description.abstractLong non-coding RNAs (lncRNAs) are a class of regulatory genes that participate in a wide range of biological processes, including proliferation, differentiation and development, as well as in a broad spectrum of diseases. Although the role of lncRNAs in TGF-β-induced epithelial-to-mesenchymal transition (EMT) has been well established, little is known about the role of lncRNAs as immediate-early regulators of EMT. Here lnc-Spry1 is identified as an immediate-early regulator of EMT that is downregulated by TGF-β. It is also found that knockdown of lnc-Spry1 promotes a mesenchymal-like phenotype and results in increased cell migration and invasion. In addition, it is shown that lnc-Spry1 depletion preferentially affects the expression of TGF-β-regulated gene targets. Moreover, lnc-Spry1 associates with U2AF65 splicing factor, suggesting a role in alternative splicing. Depletion of lnc-Spry1 induces, as TGF-β, isoform switching of fibroblast growth factor receptors, resulting in FGF-2-sensitive cells. Taken together, these results show that lnc-Spry1 could act as an early mediator of TGF-β signaling and reveal different roles for a lncRNA in modulating transcriptional and posttranscriptional gene expression.-
dc.description.sponsorshipThis work was supported by grants from Ministerio de Economía y Competitividad (SAF2014-57632-P to JAP-T). CR-M was a recipient of a predoctoral fellowship from Ministerio de Economía y Competitividad.-
dc.publisherNature Publishing Group-
dc.titleDownregulation of Lnc-Spry1 mediates TGF-β-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms-
dc.description.versionPeer Reviewed-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
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