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Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder

AuthorsHmadcha, Abdelkrim ; Aguilera, Yolanda ; Lozano-Arana, Maria Dolores; Mellado, Nuria; Perona, Javier S. ; Moya, Cristina; Sánchez-Palazón, Luis; Palacios Calvo, José ; Antiñolo, Guillermo ; Soria Escoms, Bernat
Issue Date2016
CitationStem Cell Research 16(3): 635-639 (2016)
AbstractFrom 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assumed to be genetically normal, HVR2 carrying Becker muscular dystrophy and HVR3 Hemophilia B. Despite the translocation t(9;15)(q34.3;q14) detected in HVR2, all the 3 cell lines were characterised in vitro and in vivo as normal hESCs lines and were registered in the Spanish Stem Cell Bank.
Publisher version (URL)https://doi.org/10.1016/j.scr.2016.03.012
Identifiersdoi: 10.1016/j.scr.2016.03.012
e-issn: 1876-7753
issn: 1873-5061
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