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dc.contributor.author | López-Saavedra, Ana | - |
dc.contributor.author | Gómez-Cabello, Daniel | - |
dc.contributor.author | Domínguez-Sánchez, María S. | - |
dc.contributor.author | Mejías-Navarro, Fernando | - |
dc.contributor.author | Fernández-Ávila, María Jesús | - |
dc.contributor.author | Dinant, Christoffel | - |
dc.contributor.author | Martínez-Macías, María Isabel | - |
dc.contributor.author | Bartek, Jiri | - |
dc.contributor.author | Huertas Sánchez, Pablo | - |
dc.date.accessioned | 2018-05-25T12:36:35Z | - |
dc.date.available | 2018-05-25T12:36:35Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1038/ncomms12364 | - |
dc.identifier | e-issn: 2041-1723 | - |
dc.identifier.citation | Nature Communications 7: 12364 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/165148 | - |
dc.description.abstract | There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways; in this study we took advantage of the SeeSaw Reporter, in which the repair of double-strand breaks by homology-independent or -dependent mechanisms is distinguished by the accumulation of green or red fluorescence, respectively. Using a genome-wide human esiRNA (endoribonuclease-prepared siRNA) library, we isolate genes that control the recombination/end-joining ratio. Here we report that two distinct sets of genes are involved in the control of the balance between NHEJ and HR: those that are required to facilitate recombination and those that favour NHEJ. This last category includes CCAR2/DBC1, which we show inhibits recombination by limiting the initiation and the extent of DNA end resection, thereby acting as an antagonist of CtIP. | - |
dc.description.sponsorship | This work was funded by a R + D + I grant from the Spanish Ministry of Economy and Competitivity (SAF2010-14877) and an ERC Starting Grant (DSBRECA). A.L.-S. is the recipient of a FPI fellowship from the Spanish Ministry of Economy and Competitivity, and F.M.-N. is funded with an FPU fellowship from the Spanish Ministry of Education. M.I.M.-M. was the recipient of a Juan de la Cierva Postdoctoral Grant. M.S.D.-S. received a EMBO short-term fellowship for this project. J.B. and C.D. were supported by grants from the Danish National Research Foundation (CARD; DNRF125), the Danish Council for Independent Research (DFF-1331-00262) and the Novo Nordisk Foundation (NNF16584). | - |
dc.publisher | Nature Publishing Group | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/278867 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/ncomms12364 | - |
dc.relation.publisherversion | https://doi.org/10.1038/ncomms12364 | - |
dc.date.updated | 2018-05-25T12:36:35Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Novo Nordisk Foundation | - |
dc.contributor.funder | Danish Council for Independent Research | - |
dc.contributor.funder | EMBO | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | European Research Council | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003043 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.pmid | 27503537 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
Aparece en las colecciones: | (CABIMER) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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CCAR2resect.pdf | 2,87 MB | Adobe PDF | Visualizar/Abrir |
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