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Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial

AuthorsSánchez Rodríguez, Estefanía; Lima Cabello, Elena; Biel Glesson, Sara; Fernández Navarro, José R.; Calleja, Miguel A.; Roca, María ; Espejo Calvo, Juan A.; Gil Extremera, Blas; Soria-Florido, María Trinidad; Torre, Rafael de la; Fitó, Montserrat; Covas, María Isabel; Alché Ramírez, Juan de Dios; Martínez de Victoria, Emilio; Gil, Ángel; Mesa, María D.
KeywordsOlive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Metabolic syndrome
Issue Date16-May-2018
PublisherMultidisciplinary Digital Publishing Institute
CitationNutrients 10(5): 626 (2018)
AbstractThe aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).
Description17 Páginas; 3 Figuras; 5 Tablas
Publisher version (URL)http://dx.doi.org/10.3390/nu10050626
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