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dc.contributor.authorCuevas, Anaes_ES
dc.contributor.authorGonzález-Gutiérrez, Sheilaes_ES
dc.contributor.authorRodríguez-Patón, Alfonsoes_ES
dc.contributor.authorGarcillán-Barcia, M. Pilares_ES
dc.contributor.authorCruz, Fernando de laes_ES
dc.identifier.citationXL SEBBM Congress (2017)es_ES
dc.descriptionResumen del póster presentado al XL Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM), celebrado en Barcelona del 23 al 26 de octubre de 2017.es_ES
dc.description.abstractConjugation is a natural communication mechanism among bacteria that relies in plasmids as vehicles. The conjugation hardware is highly specific and robust, allowing the independent transmission of different conjugative plasmids without interference. We constructed an E. coli derivative containing a chromosomally-inserted conjugative W-wire and engineered a recombinant plasmid series able to compute the basic logic gates YES, AND, OR. The computing strain was used as a donor in mating experiments and a reporter strain able to trigger the production of a fluorescent protein from the reporter plasmid was used as recipient. The functionality and specificity of these circuits constitute a proof of principle that cell-cell communication mediated by conjugative plasmids could be implemented as a new tool in Synthetic Biology to distribute genetic circuits in bacterial populations.es_ES
dc.titlePlasmid conjugation-based logic gateses_ES
dc.description.peerreviewedPeer reviewedes_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(IBBTEC) Comunicaciones congresos
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