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Title

Different Intestinal Microbial Profile in Over-Weight and Obese Subjects Consuming a Diet with Low Content of Fiber and Antioxidants

AuthorsFernández-Navarro, Tania; Salazar, Nuria ; Gutiérrez-Díaz, Isabel; González de los Reyes-Gavilán, Clara ; Gueimonde Fernández, Miguel ; González, Sonia
Issue Date27-May-2017
PublisherMultidisciplinary Digital Publishing Institute
CitationNutrients 9 (6): 551 (2017)
AbstractObesity has been related to an increased risk of multiple diseases in which oxidative stress and inflammation play a role. Gut microbiota has emerged as a mediator in this interaction, providing new mechanistic insights at the interface between fat metabolism dysregulation and obesity development. Our aim was to analyze the interrelationship among obesity, diet, oxidative stress, inflammation and the intestinal microbiota in 68 healthy adults (29.4% normal-weight). Diet was assessed through a food frequency questionnaire and converted into nutrients and dietary compounds using food composition tables. The intestinal microbiota was assessed by quantitative PCR, fecal short chain fatty acids by gas chromatography and serum biomarkers by standard protocols. Higher levels of malondialdehyde (MDA), C reactive protein (CRP), serum leptin, glucose, fat percentage and the intestinal <i>Lactobacillus</i> group were found in the obese people. Cluster analysis of body mass index, fat mass, glucose, LDL/HDL ratio, leptin, MDA and CRP classified the subjects into two groups. The levels of the intestinal <i>Bacteroides-Prevotella-Porphyromonas</i> group were lower in the cluster and linked to a higher pro-oxidant and pro-inflammatory status, whose individuals also had lower intake of fruits, dried fruits, and fish. These results could be useful for designing strategies targeted to obesity prevention.
Publisher version (URL)http://dx.doi.org/10.3390/nu9060551
URIhttp://hdl.handle.net/10261/164187
DOIhttp://dx.doi.org/doi: doi: 10.3390/nu9060551
Identifiersdoi: 10.3390/nu9060551
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