English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/164098
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Cytoskeleton rearrangements during the execution phase of apoptosis

AuthorsPorcuna, Jesús; Cruz, Patricia de la; Oropesa-Ávila, Manuel; Villanueva Paz, Marina; Lavera, I. de; Mata, Mario de la ; Álvarez-Córdoba, Mónica; Luzón-Hidalgo, Raquel; Suarez-Rivero, Juan M.; Cotán, David ; Sánchez-Alcázar, José Antonio
KeywordsActin Intermediate filaments
Apoptosis
Apoptotic microtubule network
Microtubules
Issue Date2016
PublisherInTech
CitationCytoskeleton. Structure, Dynamics, Function and Disease: 151-169 (2016)
AbstractApoptosis is a regulated energy-dependent process for the elimination of unnecessary or damaged cells during embryonic development, tissue homeostasis and many pathological conditions. Apoptosis is characterized by specific morphological and biochemical features in which caspase activation has a pivotal role. During apoptosis, cells undergo characteristic morphological reorganizations in which the cytoskeleton participates actively. Traditionally, this cytoskeleton rearrangement has been assigned mainly to actinomyosin ring contraction, with microtubule and intermediate filaments both reported to be depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reformed during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Current hypothesis proposes that AMN is required to maintain plasma membrane integrity and cell morphology during the execution phase of apoptosis. AMN disruption provokes apoptotic cell collapse, secondary necrosis and the subsequent release of toxic molecules which can damage surrounding cells and promote inflammation. Therefore, AMN formation in physiological or pathological apoptosis is essential for tissue homeostasis.
Publisher version (URL)https://doi.org/10.5772/66865
URIhttp://hdl.handle.net/10261/164098
Identifiersdoi: 10.5772/66865
isbn: 978-953-51-3169-4
Appears in Collections:(CABD) Libros y partes de libros
Files in This Item:
File Description SizeFormat 
CytoskeletonApoptosis.pdf4,68 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.