Identification of new pathways involved in the regulation of the UPRmt reveals a crosstalk between mitochondrial stress response and insulin signaling

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Hernando-Rodríguez, Blanca	es_ES
dc.contributor.author	Jarit-Cabanillas, Aitor	es_ES
dc.contributor.author	Kaderali, Lars	es_ES
dc.contributor.author	Artal-Sanz, Marta	es_ES
dc.date.accessioned	2018-04-24T08:37:34Z	-
dc.date.available	2018-04-24T08:37:34Z	-
dc.date.issued	2017	-
dc.identifier.citation	21st International C. elegans Conference (2017)	es_ES
dc.identifier.uri	http://hdl.handle.net/10261/164067	-
dc.description	Resumen del trabajo presentado a la 21st International C. elegans Conference of the Genetics Society of America, celebrada en California, Los Angeles (US) del 21 al 25 de junio de 2017.-- et al.	es_ES
dc.description.abstract	Depletion of the mitochondrial prohibitin complex (PHB) shows an opposite effect on aging: it shortens lifespan in wild-type worms while it dramatically extends the longevity of the already long-lived insulin/IGF-1 signaling (IIS) mutants. Moreover, PHB depletion induces a strong mitochondrial unfolded protein response (UPRmt) in wild-type animals while this response is remarkably reduced in IIS mutants. Interestingly, some of the described UPRmt components are not required for the activation of the response upon PHB depletion. We aimed at identifying new pathways involved in the regulation of the PHB-mediated mitochondrial stress response, as well as mechanisms responsible for the opposite longevity outcomes of PHB depletion. Towards this aim, we developed a semi-automated method based on double RNAi and automated image analysis to carry out RNAi screens, in PHB-depleted wild type and IIS mutants. In addition to a big number of genes involved in protein homeostasis, we describe evolutionarily conserved developmental signal transduction pathways as essential modulators of the mitochondrial stress response. Furthermore, we report pathways regulating the UPRmt in an insulin-dependent manner. Our results suggest a difference in metabolism between PHB-depleted worms and PHB-depleted;IIS mutants and place carbohydrate and lipid metabolism as possible mechanisms contributing to the opposite effect of PHB depletion in the aging phenotype of wild type and metabolically compromised animals.	es_ES
dc.language.iso	eng	es_ES
dc.rights	closedAccess	es_ES
dc.title	Identification of new pathways involved in the regulation of the UPRmt reveals a crosstalk between mitochondrial stress response and insulin signaling	es_ES
dc.type	comunicación de congreso	es_ES
dc.description.peerreviewed	Peer reviewed	es_ES
dc.relation.csic	Sí	es_ES
oprm.item.hasRevision	no ko 0 false	*
dc.type.coar	http://purl.org/coar/resource_type/c_5794	es_ES
item.openairetype	comunicación de congreso	-
item.grantfulltext	none	-
item.cerifentitytype	Publications	-
item.openairecristype	http://purl.org/coar/resource_type/c_18cf	-
item.fulltext	No Fulltext	-
item.languageiso639-1	en	-
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