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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

AuthorsCobo-Vuilleumier, Nadia ; Lorenzo, Petra Isabel ; García-Rodríguez, Noelia; Gracia Herrera-Gómez, Irene de; Fuente-Martín, Esther; López-Noriega, Livia; Mellado-Gil, José Manuel ; Romero-Zerbo, Silvana Y.; Lachaud, Christian C. ; Pozo, David ; Hmadcha, Abdelkrim ; Toscano, Miguel G. ; Sánchez Palazón, Luis; Martín-Montalvo, Alejandro ; Soria Escoms, Bernat ; Bermúdez-Silva, Francisco Javier; Gauthier, Benoit R.
KeywordsIslets of Langerhans
Type 1 diabetes
Type 2 diabetes
Issue Date16-Apr-2018
PublisherSpringer Nature
CitationNature Communications 9(1): 1488 (2018)
AbstractType 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus.
DescriptionCobo-Vuilleumier, Nadia et al.
Publisher version (URL)http://dx.doi.org/10.1038/s41467-018-03943-0
Appears in Collections:(CABIMER) Artículos
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