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A novel function of aPKC controlling apical cell trafficking

AuthorsSotillos, Sol
Issue Date2016
PublisherSociedad Española de Biología Celular
Citation11th Meeting SEBD (2016)
AbstractCell polarity is a basic characteristic of any cell, required for their proper physiological function. To establish cell polarity a number of determinants are required (reviewed in) to restrict the different functional domains in the cell. When establish and for maintenance of cell polarity a proper trafficking to and recycling from the membrane is required. And, vice versa, once established cell polarity is necessary to define the cell domains for trafficking delivery. Thus, an intermingled between cell polarity and cell trafficking is essential to maintain each other and for the proper cell physiology. Recently we have shown a new interacting point between cell polarity and trafficking at the level of the polarity determinant aPKC and the Rab11-adaptor protein Nuclear fallout (Nuf). aPKC is a Ser/Thr kinase of the Par complex essential in most of the polarity processes. Nuf belongs to the Rab11-family interacting proteins (Rab11-FIP) that function as an adaptor of Rab11 to the microtubule motor protein kinesin and the dynein complex. We have demonstrated that active aPKC interacts directly with and phosphorylates Nuf, modifying its cellular distribution. Furthermore, aPKC is a cargo of the Nuf-Rab11 recycling endosomes and it seems to be regulating its own recycling in the cell by phosphorylation and displacement of Nuf from the apico-lateral cortex. I will present new data showing how Nuf-Rab11-RE are also required during embryogenesis to sustain the apical cell polarity, affecting mainly to aPKC membrane maintenance. However, in contrast with data from vertebrates Rab11-REs are not required to establish cell polarity during early embryogenesis.
DescriptionTrabajo presentado al 11th Meeting of the Spanish Society for Developmental Biology, celebrado en Girona (España) del 19 al 21 de octubre de 2016.-- Tambien presentado al XXXIX Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM), celebrado en Salamanca del 5 al 8 de septiembre de 2016.
Appears in Collections:(CABD) Comunicaciones congresos
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