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Título: | The evolutionary origins of cell type diversification and the role of intrinsically disordered proteins |
Autor: | Niklas, Karl J.; Dunker, A. Keith; Yruela Guerrero, Inmaculada CSIC ORCID | Palabras clave: | Alternative splicing Complex multicellularity Evolution Gene regulatory networks post-translational modification |
Fecha de publicación: | mar-2018 | Editor: | Oxford University Press | Citación: | Niklas KJ, Dunker AK, Yruela I. The evolutionary origins of cell type diversification and the role of intrinsically disordered proteins. Journal of Experimental Botany 69 (7): 1437-1446 (2018) | Resumen: | The evolution of complex multicellular life forms occurred multiple times and was attended by cell type specialization. We review seven lines of evidence indicating that intrinsically disordered/ductile proteins (IDPs) played a significant role in the evolution of multicellularity and cell type specification: (i) most eukaryotic transcription factors (TFs) and multifunctional enzymes contain disproportionately long IDP sequences (≥30 residues in length), whereas highly conserved enzymes are normally IDP region poor; (ii) ~80% of the proteome involved in development are IDPs; (iii) the majority of proteins undergoing alternative splicing (AS) of pre-mRNA contain significant IDP regions; (iv) proteins encoded by DNA regions flanking crossing-over ‘hot spots’ are significantly enriched in IDP regions; (v) IDP regions are disproportionately subject to combinatorial post-translational modifications (PTMs) as well as AS; (vi) proteins involved in transcription and RNA processing are enriched in IDP regions; and (vii) a strong positive correlation exists between the number of different cell types and the IDP proteome fraction across a broad spectrum of uni- and multicellular algae, plants, and animals. We argue that the multifunctionalities conferred by IDPs and the disproportionate involvement of IDPs with AS and PTMs provided a IDP–AS–PTM ‘motif’ that significantly contributed to the evolution of multicellularity in all major eukaryotic lineages. | Descripción: | 30 pags.- 1 Tabl. 4 Figs. The definitive version is available at: https://academic.oup.com/jxb | Versión del editor: | https://doi.org/10.1093/jxb/erx493 | URI: | http://hdl.handle.net/10261/163531 | DOI: | 10.1093/jxb/erx493 | ISSN: | 0022-0957 | E-ISSN: | 1460-2431) |
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YruelaI_JExpBot_2018.pdf | 1,68 MB | Adobe PDF | Visualizar/Abrir |
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