English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/163531
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
DC FieldValueLanguage
dc.contributor.authorNiklas, Karl J.es_ES
dc.contributor.authorDunker, A. Keithes_ES
dc.contributor.authorYruela Guerrero, Inmaculadaes_ES
dc.identifier.citationNiklas KJ, Dunker AK, Yruela I. The evolutionary origins of cell type diversification and the role of intrinsically disordered proteins. Journal of Experimental Botany 69 (7): 1437-1446 (2018)es_ES
dc.description30 pags.- 1 Tabl. 4 Figs. The definitive version is available at: https://academic.oup.com/jxbes_ES
dc.description.abstractThe evolution of complex multicellular life forms occurred multiple times and was attended by cell type specialization. We review seven lines of evidence indicating that intrinsically disordered/ductile proteins (IDPs) played a significant role in the evolution of multicellularity and cell type specification: (i) most eukaryotic transcription factors (TFs) and multifunctional enzymes contain disproportionately long IDP sequences (≥30 residues in length), whereas highly conserved enzymes are normally IDP region poor; (ii) ~80% of the proteome involved in development are IDPs; (iii) the majority of proteins undergoing alternative splicing (AS) of pre-mRNA contain significant IDP regions; (iv) proteins encoded by DNA regions flanking crossing-over ‘hot spots’ are significantly enriched in IDP regions; (v) IDP regions are disproportionately subject to combinatorial post-translational modifications (PTMs) as well as AS; (vi) proteins involved in transcription and RNA processing are enriched in IDP regions; and (vii) a strong positive correlation exists between the number of different cell types and the IDP proteome fraction across a broad spectrum of uni- and multicellular algae, plants, and animals. We argue that the multifunctionalities conferred by IDPs and the disproportionate involvement of IDPs with AS and PTMs provided a IDP–AS–PTM ‘motif’ that significantly contributed to the evolution of multicellularity in all major eukaryotic lineages.es_ES
dc.description.sponsorshipThis work was supported by grants from Ministerio de Economía y Competitividad (BIO2016-75183-P) and Gobierno de Aragón (DGA-GC B18), which were partially funded by the EU FEDER Program. Funding from the College of Agriculture and Life Sciences, Cornell University, is also gratefully acknowledged.es_ES
dc.publisherOxford University Presses_ES
dc.subjectalternative splicinges_ES
dc.subjectcomplex multicellularityes_ES
dc.subjectgene regulatory networkses_ES
dc.subjectpost-translational modificationes_ES
dc.titleThe evolutionary origins of cell type diversification and the role of intrinsically disordered proteinses_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderGobierno de Aragónes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderCornell Universityes_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(EEAD) Artículos
Files in This Item:
File Description SizeFormat 
YruelaI_JExpBot_2018.pdf1,68 MBAdobe PDFThumbnail
Show simple item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.