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The evolutionary origins of cell type diversification and the role of intrinsically disordered proteins

AuthorsNiklas, Karl J.; Dunker, A. Keith; Yruela Guerrero, Inmaculada
Keywordsalternative splicing
complex multicellularity
gene regulatory networks
post-translational modification
Issue DateMar-2018
PublisherOxford University Press
CitationNiklas KJ, Dunker AK, Yruela I. The evolutionary origins of cell type diversification and the role of intrinsically disordered proteins. Journal of Experimental Botany 69 (7): 1437-1446 (2018)
AbstractThe evolution of complex multicellular life forms occurred multiple times and was attended by cell type specialization. We review seven lines of evidence indicating that intrinsically disordered/ductile proteins (IDPs) played a significant role in the evolution of multicellularity and cell type specification: (i) most eukaryotic transcription factors (TFs) and multifunctional enzymes contain disproportionately long IDP sequences (≥30 residues in length), whereas highly conserved enzymes are normally IDP region poor; (ii) ~80% of the proteome involved in development are IDPs; (iii) the majority of proteins undergoing alternative splicing (AS) of pre-mRNA contain significant IDP regions; (iv) proteins encoded by DNA regions flanking crossing-over ‘hot spots’ are significantly enriched in IDP regions; (v) IDP regions are disproportionately subject to combinatorial post-translational modifications (PTMs) as well as AS; (vi) proteins involved in transcription and RNA processing are enriched in IDP regions; and (vii) a strong positive correlation exists between the number of different cell types and the IDP proteome fraction across a broad spectrum of uni- and multicellular algae, plants, and animals. We argue that the multifunctionalities conferred by IDPs and the disproportionate involvement of IDPs with AS and PTMs provided a IDP–AS–PTM ‘motif’ that significantly contributed to the evolution of multicellularity in all major eukaryotic lineages.
Description30 pags.- 1 Tabl. 4 Figs. The definitive version is available at: https://academic.oup.com/jxb
Publisher version (URL)https://doi.org/10.1093/jxb/erx493
Appears in Collections:(EEAD) Artículos
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