English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/163425
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorDobrzynska, Agnieszka-
dc.contributor.authorGonzalo, Susana-
dc.contributor.authorShanahan, Catherine-
dc.contributor.authorAskjaer, Peter-
dc.date.accessioned2018-04-10T12:09:52Z-
dc.date.available2018-04-10T12:09:52Z-
dc.date.issued2016-
dc.identifierdoi: 10.1080/19491034.2016.1183848-
dc.identifierissn: 1949-1042-
dc.identifier.citationNucleus 7(3): 233-248 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/163425-
dc.description.abstractThe nuclear lamina (NL) is a structural component of the nuclear envelope and makes extensive contacts with integral nuclear membrane proteins and chromatin. These interactions are critical for many cellular processes, such as nuclear positioning, perception of mechanical stimuli from the cell surface, nuclear stability, 3-dimensional organization of chromatin and regulation of chromatin-binding proteins, including transcription factors. The NL is present in all nucleated metazoan cells but its composition and interactome differ between tissues. Most likely, this contributes to the broad spectrum of disease manifestations in humans with mutations in NL-related genes, ranging from muscle dystrophies to neurological disorders, lipodystrophies and progeria syndromes. We review here exciting novel insight into NL function at the cellular level, in particular in chromatin organization and mechanosensation. We also present recent observations on the relation between the NL and metabolism and the special relevance of the NL in muscle tissues. Finally, we discuss new therapeutic approaches to treat NL-related diseases.-
dc.description.sponsorshipWork in the SG lab was supported by NIH RO1 GM094513-01. Work in the PA lab is funded by the Spanish Ministry of Economy and Competitiveness [BFU2013-42709P] and the European Regional Development Fund.-
dc.publisherTaylor & Francis-
dc.relationMINECO/ICTI2013-2016/BFU2013-42709-P-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectFarnesylation-
dc.subjectMetabolism-
dc.subjectMuclear lamina-
dc.subjectMuclear envelope-
dc.subjectChromatin-
dc.subjectEmerin-
dc.subjectMuscles-
dc.subjectHutchinson-Gilford progeria syndrome-
dc.subjectLaminopathies-
dc.subjectLAP2-
dc.subjectLBR-
dc.subjectMechanotransduction-
dc.titleThe nuclear lamina in health and disease-
dc.typeartículo-
dc.relation.publisherversionhttp://dx.doi.org/10.1080/19491034.2016.1183848-
dc.date.updated2018-04-10T12:09:52Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc/3.0/-
dc.contributor.funderNational Institutes of Health (US)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.pmid27158763-
Appears in Collections:(CABD) Artículos
Files in This Item:
File Description SizeFormat 
nuclamisease.pdf894,2 kBAdobe PDFThumbnail
View/Open
Show simple item record
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.