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Title

Targeting autophagy and mitophagy for mitochondrial diseases treatment

AuthorsVillanueva Paz, Marina; Cotán, David ; Garrido-Maraver, Juan; Cordero, Mario D. ; Oropesa-Ávila, Manuel; Mata, Mario de la ; Delgado Pavón, Ana; Lavera, I. de; Alcocer-Gómez, Elísabet; Sánchez-Alcázar, José Antonio
KeywordsROS
Rapamycin
Mitophagy
Mitochondrial dynamics
mTOR
Heteroplasmy
AICAR
AMPK
Parkin
Autophagy
Coenzyme Q10
Issue Date2016
PublisherTaylor & Francis
CitationExpert Opinion on Therapeutic Targets 20(4): 487-500 (2016)
Abstract[Introduction]: Mitochondrial diseases are a group of rare genetic diseases with complex and heterogeneous origins which manifest a great variety of phenotypes. Disruption of the oxidative phosphorylation system is the main cause of pathogenicity in mitochondrial diseases since it causes accumulation of reactive oxygen species (ROS) and ATP depletion. [Areas covered]: Current evidences support the main protective role of autophagy and mitophagy in mitochondrial diseases and other diseases associated with mitochondrial dysfunction. [Expert Opinion]: The use of autophagy and/or mitophagy inducers may allow a novel strategy for improving mitochondrial function for both mitochondrial diseases and other diseases with altered mitochondrial metabolism. However, a deeper investigation of the molecular mechanisms behind mitophagy and mitochondrial biogenesis is needed in order to safely modulate these processes. In the coming years, we will also see an increase in awareness of mitochondrial dynamics modulation that will allow the therapeutic use of new drugs for improving mitochondrial function in a great variety of mitochondrial disorders.
URIhttp://hdl.handle.net/10261/163424
Identifiersdoi: 10.1517/14728222.2016.1101068
issn: 1472-8222
e-issn: 1744-7631
Appears in Collections:(CABD) Artículos
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