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Title

Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics

AuthorsNalls, Michael A.; Simón-Sánchez, Javier ; Gibbs, J. Raphael; Paisan-Ruiz, Coro; Bras, Jose Tomas; Tanaka, Toshiko; Matarin, Mar; Scholz, Sonja; Weitz, Charles; Harris, Tamara B.; Ferrucci, Luigi; Hardy, John; Singleton, Andrew B.
Issue Date13-Mar-2009
PublisherPublic Library of Science
CitationPLoS Genet;5 (3): e1000415
AbstractThis research investigates the influence of demographic factors on human genetic sub-structure. In our discovery cohort, we show significant demographic trends for decreasing autozygosity associated with population variation in chronological age. Autozygosity, the genomic signature of consanguinity, is identifiable on a genome-wide level as extended tracts of homozygosity. We identified an average of 28.6 tracts of extended homozygosity greater than 1 Mb in length in a representative population of 809 unrelated North Americans of European descent ranging in chronological age from 19-99 years old. These homozygous tracts made up a population average of 42 Mb of the genome corresponding to 1.6% of the entire genome, with each homozygous tract an average of 1.5 Mb in length. Runs of homozygosity are steadily decreasing in size and frequency as time progresses (linear regression, p<0.05). We also calculated inbreeding coefficients and showed a significant trend for population-wide increasing heterozygosity outside of linkage disequilibrium. We successfully replicated these associations in a demographically similar cohort comprised of a subgroup of 477 Baltimore Longitudinal Study of Aging participants. We also constructed statistical models showing predicted declining rates of autozygosity spanning the 20th century. These predictive models suggest a 14.0% decrease in the frequency of these runs of homozygosity and a 24.3% decrease in the percent of the genome in runs of homozygosity, as well as a 30.5% decrease in excess homozygosity based on the linkage pruned inbreeding coefficients. The trend for decreasing autozygosity due to panmixia and larger effective population sizes will likely affect the frequency of rare recessive genetic diseases in the future. Autozygosity has declined, and it seems it will continue doing so
Description7 pages, 1 figure.-- 19282984 [PubMed}
Publisher version (URL)htpp://dx.doi.org/10.1371/journal.pgen.1000415
URIhttp://hdl.handle.net/10261/16325
DOI10.1371/journal.pgen.1000415
ISSN1553-7404
Appears in Collections:(IBV) Artículos
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