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Title

Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell

AuthorsMarco, Antonio; Marín, Ignacio
Issue Date15-Jul-2009
PublisherBioMed Central
CitationBMC Systems Biology 2009, 3:69
AbstractBACKGROUND: The characterization of the global functional structure of a cell is a major goal in bioinformatics and systems biology. Gene Ontology (GO) and the protein-protein interaction network offer alternative views of that structure. RESULTS: This study presents a comparison of the global structures of the Gene Ontology and the interactome of Saccharomyces cerevisiae. Sensitive, unsupervised methods of clustering applied to a large fraction of the proteome led to establish a GO-interactome correlation value of +0.47 for a general dataset that contains both high and low-confidence interactions and +0.58 for a smaller, high-confidence dataset. CONCLUSION: The structures of the yeast cell deduced from GO and interactome are substantially congruent. However, some significant differences were also detected, which may contribute to a better understanding of cell function and also to a refinement of the current ontologies
Description15 pages, 6 figures.-- 19604360 [PubMed]
Publisher version (URL)htpp://dx.doi.org/10.1186/1752-0509-3-69
URIhttp://hdl.handle.net/10261/16318
DOI10.1186/1752-0509-3-69
ISSN1752-0509
Appears in Collections:(IBV) Artículos
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