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AMPK as a target in rare diseases

AuthorsCotán, David ; Alcocer-Gómez, Elísabet; Garrido-Maraver, Juan; Oropesa-Ávila, Manuel; Mata, Mario de la ; Lavera, I. de; Galán, Fernando; Ybot, Patricia; Sánchez-Alcázar, José Antonio
Issue Date2016
PublisherBentham Science Publishers
CitationCurrent Drug Targets 17(8): 921-931 (2016)
AbstractThe AMP-activated protein kinase (AMPK) has emerged as an important sensor of signals that control cellular energy balance in all eukaryotes. AMPK is also involved in fatty acid oxidation, glucose transport, antioxidant defense, mitochondrial biogenesis and the modulation of inflammatory processes. The numerous roles of AMPK in cell physiological and pathological states justified the notable increase in the number of publications in previous years, with almost 1500 scientific articles relative to this kinase in 2014. Due to its role in maintaining energy balance, a dysfunction in AMPK signalling pathway may result in perturbations at the systemic level that contribute to the development of many disease conditions. Among them, more than 7000 poorly-known rare diseases are particularly of social and scientific interest because they are usually chronically debilitating or even lifethreatening and lack effective and safe treatment. Several authors have demonstrated AMPK alterations and the beneficial effect of treatments with drugs regulating AMPK activity in some of these low prevalence pathologies. Among these rare diseases in which AMPK can play an important pathological role are mitochondrial disorders, muscular dystrophies, cardiovascular diseases, neurodegenerative pathologies, or even some types of cancer for the importance of AMPK as a suppressor of cell proliferation. This review focuses on current knowledge about the pathophysiological roles of AMPK and future approaches as therapeutic targeting in rare diseases.
Identifiersdoi: 10.2174/1389450117666160112110204
e-issn: 1873-5592
issn: 1389-4501
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