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Title

Contribution of bioactive hyaluronic acid and gelatin to regenerative medicine. Methodologies of gels preparation and advanced applications

AuthorsMora-Boza, Ana; Puertas-Bartolomé, María; Vázquez-Lasa, Blanca ; San Román, Julio ; Pérez-Caballer, Antonio; Olmeda-Lozano, Marta
Issue Date2017
PublisherElsevier
CitationEuropean Polymer Journal 95: 11-26 (2017)
AbstractAn overview of the most relevant crosslinking processes and agents that are being developed for regenerative medicine, including different hydrogel modifications as well as several interesting and advanced applications. The functionality and reactivity of polysaccharides and in particular hyaluronic acid in combination with proteins like gelatin, collagen and many others offer very interesting opportunities for the new trends in regenerative medicine. The biomimetic approaches for the application in regenerative processes and tissue engineering have enormous possibilities because of the excellent response of these biomimetic materials and their bioactive and biodegradable character in the human body. These characteristics together with the possibility of application by minimally invasive surgery offer very interesting applications in regeneration of tissues and organs, as well as in targeting and releasing of bioactive compounds applications as drug delivery systems. In addition, the growing of clinical applications of these macromolecular components as assemblies opens new and advanced opportunities in regenerative medicine and drug delivery fields.
Publisher version (URL)http://dx.doi.org/10.1016/j.eurpolymj.2017.07.039
URIhttp://hdl.handle.net/10261/162523
Identifiersdoi: 10.1016/j.eurpolymj.2017.07.039
issn: 0014-3057
e-issn: 1873-1945
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