English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/161882
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorChiner-Oms, Álvaroes_ES
dc.contributor.authorGonzález-Candelas, Fernandoes_ES
dc.contributor.authorComas, Iñakies_ES
dc.date.accessioned2018-03-09T07:44:00Z-
dc.date.available2018-03-09T07:44:00Z-
dc.date.issued2018-02-28-
dc.identifier.citationScientific Reports 8(1):3813 (2018)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/161882-
dc.description13 Páginas, 7 figuras . Contiene información suplementaria en : 10.1038/s41598-018-22237-5es_ES
dc.description.abstractEvery year, species of the Mycobacterium tuberculosis complex (MTBC) kill more people than any other infectious disease caused by a single agent. As a consequence of its global distribution and parallel evolution with the human host the bacteria is not genetically homogeneous. The observed genetic heterogeneity has relevance at different phenotypic levels, from gene expression to epidemiological dynamics. However, current systems biology datasets have focused on the laboratory reference strain H37Rv. By using large expression datasets testing the role of almost two hundred transcription factors, we have constructed computational models to grab the expression dynamics of Mycobacterium tuberculosis H37Rv genes. However, we have found that many of those transcription factors are deleted or likely dysfunctional across strains of the MTBC. As a result, we failed to predict expression changes in strains with a different genetic background when compared with experimental data. These results highlight the importance of designing systems biology approaches that take into account the genetic diversity of tubercle bacilli, or any other pathogen, if we want to identify universal targets for vaccines, diagnostics and treatments.es_ES
dc.description.sponsorshipThis work was funded by projects BFU2014-58656-R and BFU2017-89594-R from Ministerio de Economía y Competitividad (Spanish Government) and PROMETEO/2016/122 from Generalitat Valenciana (to FGC), Ministerio de Economía y Competitividad (Spanish Government) research grant SAF2016-77346-R, and the European Research Council (ERC) (638553-TB-ACCELERATE) (to IC). ACO is recipient of a FPU fellowship from Ministerio de Educación y Ciencia FPU13/00913 (Spanish Government).es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relationMINECO/ICTI2013-2016/BFU2014/58656-Res_ES
dc.relationMINECO/ICTI2013-2016/BFU2017/89594-Res_ES
dc.relationMINECO/ICTI2013-2016/SAF2016/77346-Res_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/638553es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleGene expression models based on a reference laboratory strain are poor predictors of Mycobacterium tuberculosis complex transcriptional diversityes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/s41598-018-22237-5-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/s41598-018-22237-5es_ES
dc.identifier.e-issn2045-2322-
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
Appears in Collections:(IBV) Artículos
Files in This Item:
File Description SizeFormat 
2018_Scientific Reports_Article_22237.pdf3,16 MBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.