Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/159516
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Protein kinase C δ regulates the clearance of actin at the immunological synapse required for polarized exosome secretion by T cells |
Autor: | Herranz, Gonzalo CSIC; Aguilera, Pablo; Dávila, Sergio; Sánchez, Alicia; Stancu, Bianca; Gómez, Jesús; Fernández, David; Martín, Raúl de; Quintanilla, Mario; Fernández, Teresa; Rodríguez, Pablo; Calvo, Victor CSIC ORCID; Izquierdo, Manuel CSIC ORCID | Fecha de publicación: | 2017 | Citación: | EMBO Conference (2017) | Resumen: | Multivesicular bodies (MVB) enclose intraluminal vesicles (ILV) formed by inward budding from the membrane of endosomes. In T lymphocytes, ILV are secreted as Fas ligand-bearing, pro-apoptotic exosomes following T cell receptor (TCR)-induced fusion of the MVB with the plasma membrane at the immune synapse (IS). Diacylglycerol (DAG) and DAG kinase α (DGKα) regulate the polarized traffic of MVB towards the IS in T lymphocytes and exosome secretion. We show that Protein Kinase Cδ (PKCδ) regulates TCR-controlled, MVB polarization towards the IS and exosome secretion. Concomitantly, we demonstrate defects in activation-induced cell death in PKCδ-interfered T lymphocytes. Spatiotemporal reorganization of actin at the IS is controlled by PKCδ. TCR-controlled phosphorylation of T538 residue of adaptor paxillin at the microtubule organizing centre (MTOC) is decreased in PKCδ-interfered cells. PKCδ-dependent actin reorganization at the IS is a key regulator of MVB polarized secretory traffic. | Descripción: | Resumen del póster presentado a la EMBO Conference: Cell polarity and membrane dynamics, celebrada en Sant Feliu de Guixols (España) del 4 al 9 de junio de 2017. | URI: | http://hdl.handle.net/10261/159516 |
Aparece en las colecciones: | (IIBM) Comunicaciones congresos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
225
checked on 28-mar-2024
Download(s)
31
checked on 28-mar-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.