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Genomic Epidemiology of Tuberculosis

AuthorsComas, Iñaki
Genome sequencing
Mutation rate
Issue Date2017
PublisherSpringer Nature
CitationStrain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control 4: 79-93 (2017)
SeriesAdvances in Experimental Medicine and Biology
AbstractThe application of next generation sequencing technologies has opened the door to a new molecular epidemiology of tuberculosis, in which we can now look at transmission at a resolution not possible before. At the same time, new technical and analytical challenges have appeared, and we are still exploring the wider potential of this new technology. Whole genome sequencing in tuberculosis still requires bacterial cultures. Thus, although whole genome sequencing has revolutionized the interpretation of transmission patterns, it is not yet ready to be applied at the point-of-care. In this chapter, I will review the promises and challenges of genomic epidemiology, as well as some of the new questions that have arisen from the use of this new technology. In addition, I will examine the role of molecular epidemiology within the general frame of global tuberculosis control and how genomic epidemiology can contribute towards the elimination of the disease.
DescriptionGagneux, S. (ed) .-- 16 páginas
Publisher version (URL)http://dx.doi.org/ 10.1007/978-3-319-64371-7_4
Appears in Collections:(IBV) Libros y partes de libros
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