English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/159411
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Antiviral Activity of Self-Assembled Glycodendro[60]fullerene Monoadducts

AuthorsMuñoz, Ángeles; Illescas, Beatriz M.; Luczkowiak, Joanna; Ribeiro-Viana, Renato ; Rojo, Javier ; Delgado, Rafael; Martín, Nazario
Issue Date2017
PublisherRoyal Society of Chemistry (UK)
CitationJournal of Materials Chemistry B 5: 6566- 6571 (2017)
AbstractA series of amphiphilic glycodendro[60]fullerene monoadducts were efficiently synthesized using the CuAAC “click chemistry” approach. These glycodendrofullerenes can self-assemble in aqueous media, in a process favoured through π- π interactions between the [60]fullerene moieties. This aggregation process leads to big and well-defined compact micelles with a uniform size and spherical-shape. The supramolecular aggregate was characterized using electronic microscopy (SEM and TEM), light scattering methods (DLS) and X-ray methodologies (SAXS and XRD). The antiviral efficiency of these aggregates has been tested in an experimental infection assay using Ebola virus glycoprotein (EboGP) pseudotyped viral particles on Jurkat cells overexpressing DC-SIGN and it is observed an improvement of the IC50 value with respect to other systems endowed with a higher number of carbohydrate ligands.
Identifiersdoi: 10.1039/C7TB01379E
issn: 2050-750X
Appears in Collections:(IIQ) Artículos
Files in This Item:
File Description SizeFormat 
JMCB_MS_revision_060617.pdf786,88 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.