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dc.contributor.authorGordon, Sean P.es_ES
dc.contributor.authorContreras-Moreira, Brunoes_ES
dc.contributor.authorWoods, Daniel P.es_ES
dc.contributor.authorDes Marais, David L.es_ES
dc.contributor.authorBurgess, Dianees_ES
dc.contributor.authorShu, Shengqianges_ES
dc.contributor.authorStritt, Christophes_ES
dc.contributor.authorRoulin, Anne C.es_ES
dc.contributor.authorSchackwitz, Wendyes_ES
dc.contributor.authorTyler, Ludmilaes_ES
dc.contributor.authorMartin, Joeles_ES
dc.contributor.authorLipzen, Annaes_ES
dc.contributor.authorDochy, Niklases_ES
dc.contributor.authorPhillips, Jeremyes_ES
dc.contributor.authorBarry, Kerriees_ES
dc.contributor.authorGeuten, Koenes_ES
dc.contributor.authorBudak, Hikmetes_ES
dc.contributor.authorJuenger, Thomas E.es_ES
dc.contributor.authorAmasino, Richardes_ES
dc.contributor.authorCaicedo, Ana L.es_ES
dc.contributor.authorGoodstein, Davides_ES
dc.contributor.authorDavidson, Patrickes_ES
dc.contributor.authorMur, Luis A. J.es_ES
dc.contributor.authorFigueroa, Melaniaes_ES
dc.contributor.authorFreeling, Michaeles_ES
dc.contributor.authorCatalán, Pilares_ES
dc.contributor.authorVogel, John P.es_ES
dc.identifier.citationGordon SP, Contreras-Moreira B, Woods DP, Des MaraisDL, Burgess D, Shu S, Stritt C, Roulin AC, Schackwitz W, Tyler L, Martin J, Lipzen A, Dochy N, Phillips J, Barry K, Geuten K, Budak H, Juenger TE, Amasino R, Caicedo A, Goodstein D, Davidson P, Mur LAJ, Figueroa M, Freeling M, Catalán P, Vogel JP. Extensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure. Nature Communications 8: Article n. 2184 (2017)es_ES
dc.description13 Pags.- 6 Figs. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holderes_ES
dc.description.abstractWhile prokaryotic pan-genomes have been shown to contain many more genes than any individual organism, the prevalence and functional significance of differentially present genes in eukaryotes remains poorly understood. Whole-genome de novo assembly and annotation of 54 lines of the grass Brachypodium distachyon yield a pan-genome containing nearly twice the number of genes found in any individual genome. Genes present in all lines are enriched for essential biological functions, while genes present in only some lines are enriched for conditionally beneficial functions (e.g., defense and development), display faster evolutionary rates, lie closer to transposable elements and are less likely to be syntenic with orthologous genes in other grasses. Our data suggest that differentially present genes contribute substantially to phenotypic variation within a eukaryote species, these genes have a major influence in population genetics, and transposable elements play a key role in pan-genome evolution.es_ES
dc.description.sponsorshipThe work conducted by the US DOE Joint Genome Institute is supported by the Office of Science of the US Department of Energy under Contract no. DE-AC02-05CH11231. D.P. W. and R.A. were funded in part by the National Science Foundation (grant no. IOS–1258126), and the Great Lakes Bioenergy Research Center (Department of Energy Biological and Environmental Research Office of Science grant no. DE– FCO2–07ER64494). TEJ and DLDM were supported by NSF PGRP grant IOS-0922457. P.C. and B.C.M. were funded by Spanish MINECO (CGL2012-39953-C02-01 and CGL2016-79790-P). B.C.M. was partially funded by DGA—Obra Social La Caixa (grant number GA-LC-059-2011) and Spanish MINECO (AGL2013-48756-R, CSIC13-4E-2490). PC was partially funded by Spanish Aragon Government-European Social Fund (Bioflora).es_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleExtensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structurees_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderDepartment of Energy (US)es_ES
dc.contributor.funderNational Science Foundation (US)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderObra Social la Caixaes_ES
dc.contributor.funderGobierno de Aragónes_ES
dc.contributor.funderEuropean Commissiones_ES
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