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dc.contributor.authorNadal, Inmaculada-
dc.contributor.authorSantacruz, Arlette-
dc.contributor.authorMarcos, Ascensión-
dc.contributor.authorWärnberg, Julia-
dc.contributor.authorGaragorri, Jesús M.-
dc.contributor.authorMoreno, Luis A.-
dc.contributor.authorMartín-Matillas, Miguel-
dc.contributor.authorCampoy, Cristina-
dc.contributor.authorMartí, Amelia-
dc.contributor.authorMoleres, A.-
dc.contributor.authorDelgado, Manuel-
dc.contributor.authorVeiga, Óscar-
dc.contributor.authorGarcía-Fuentes, Miguel-
dc.contributor.authorRedondo, Carlos-
dc.contributor.authorSanz, Yolanda-
dc.identifier.citationInternational Journal of Obesity (2009) 33, 758–767en_US
dc.description10 pages, 4 tables, 3 figures.-- Online version published 9 December 2008en_US
dc.description.abstract[Objective]: To evaluate the effects of a multidisciplinary obesity treatment programme on fecal microbiota composition and immunoglobulin-coating bacteria in overweight and obese adolescents and their relationship to weight loss.en_US
dc.description.abstract[Design]: Longitudinal intervention study based on both a calorie-restricted diet (calorie reduction=10–40%) and increased physical activity (calorie expenditure=15–23 kcal/kg body weight per week) for 10 weeks.en_US
dc.description.abstract[Participants]: Thirty-nine overweight and obese adolescents (BMI mean 33.1 range 23.7–50.4; age mean 14.8 range, 13.0–16.0).en_US
dc.description.abstract[Measurements]: BMI, BMI z-scores and plasma biochemical parameters were measured before and after the intervention. Fecal microbiota was analyzed by fluorescent in situ hybridization. Immunoglobulin-coating bacteria were detected using fluorescent-labelled F(ab')2 antihuman IgA, IgG and IgM.en_US
dc.description.abstract[Results]: Reductions in Clostridium histolyticum and E. rectale-C. coccoides proportions significantly correlated with weight and BMI z-score reductions in the whole adolescent population. Proportions of C. histolyticum, C. lituseburense and E. rectale-C. coccoides dropped significantly whereas those of the Bacteroides-Prevotella group increased after the intervention in those adolescents who lost more than 4 kg. Total fecal energy was almost significantly reduced in the same group of adolescents but not in the group that lost less than 2.5 kg. IgA-coating bacterial proportions also decreased significantly in participants who lost more than 6 kg after the intervention, paralleled to reductions in C. histolyticum and E. rectale-C. coccoides populations. E. rectale-C. coccoides proportions also correlated with weight loss and BMI z-score reduction in participants whose weight loss exceeded 4 kg.en_US
dc.description.abstract[Conclusions]: Specific gut bacteria and an associated IgA response were related to body weight changes in adolescents under lifestyle intervention. These results suggest interactions between diet, gut microbiota and host metabolism and immunity in obesity.en_US
dc.description.sponsorshipThis work was supported by grants AGL2005- 05788-C02-01 from the Spanish Ministry of Education (MEC) and AP 002/07 from Consejería de Sanidad (Valencia, Spain). The EVASYON study was supported by grants from Spanish Ministry of Health (PI051574).en_US
dc.format.extent214191 bytes-
dc.publisherNature Publishing Groupen_US
dc.subjectWeight managementen_US
dc.titleShifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescentsen_US
dc.description.peerreviewedPeer revieweden_US
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