English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/158544
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Similar genomic proportions of copy number variation within gray wolves and modern dog breeds inferred from whole genome sequencing

AuthorsSerres-Armero, Aitor; Povolotskaya, Inna S.; Quilez, Javier ; Ramírez, Óscar ; Santpere, Gabriel ; Kuderna, Lukas F. K.; Hernández-Rodríguez, Jessica; Fernández-Callejo, Marcos; Gómez-Sánchez, Daniel; Freedman, Adam H.; Fan, Zhenxin; Novembre, John; Navarro, Arcadi ; Boyko, Adam; Wayne, Robert; Vilà, Carles ; Lorente-Galdós, Belén ; Marqués-Bonet, Tomàs
Issue Date19-Dec-2017
PublisherBioMed Central
CitationBMC Genomics 18(1):977 (2017)
AbstractAbstract Background Whole genome re-sequencing data from dogs and wolves are now commonly used to study how natural and artificial selection have shaped the patterns of genetic diversity. Single nucleotide polymorphisms, microsatellites and variants in mitochondrial DNA have been interrogated for links to specific phenotypes or signals of domestication. However, copy number variation (CNV), despite its increasingly recognized importance as a contributor to phenotypic diversity, has not been extensively explored in canids. Results Here, we develop a new accurate probabilistic framework to create fine-scale genomic maps of segmental duplications (SDs), compare patterns of CNV across groups and investigate their role in the evolution of the domestic dog by using information from 34 canine genomes. Our analyses show that duplicated regions are enriched in genes and hence likely possess functional importance. We identify 86 loci with large CNV differences between dogs and wolves, enriched in genes responsible for sensory perception, immune response, metabolic processes, etc. In striking contrast to the observed loss of nucleotide diversity in domestic dogs following the population bottlenecks that occurred during domestication and breed creation, we find a similar proportion of CNV loci in dogs and wolves, suggesting that other dynamics are acting to particularly select for CNVs with potentially functional impacts. Conclusions This work is the first comparison of genome wide CNV patterns in domestic and wild canids using whole-genome sequencing data and our findings contribute to study the impact of novel kinds of genetic changes on the evolution of the domestic dog.
Publisher version (URL)http://dx.doi.org/10.1186/s12864-017-4318-x
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
12864_2017_Article_4318.pdf1,27 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.